Diving into the Project
Optical microscopy constitutes one of the most fundamental paradigms in biological and medical imaging. However, significant challenges remain in regard to the application of optical microscopy to in vivo interrogations. First, the diffusing nature of light propagation in tissue due to random variations of the refractive index, limits in vivo microscopy to superficial depths; within only a few mean free paths (<1mm). Second the invasive nature of fluorescent proteins and probes, allows monitoring of only 1-5 events by spectrally multiplexing different fluorochromes; i.e. performance that is highly incompatible with the targets of functional genomics and proteomics.
This proposal aims to develop the next step in optical visualization by addressing these two fundamental limitations of optical imaging, i.e. Depth and Contrast. To achieve this, DynAMic proposes a radically new concept for optical imaging of tissue based on
The new optical imaging ability delivered in DynAMic will be applied to a first target application of ophthalmic imaging, also used as a window to the brain and nervous disease detection, defining the next generation ophthalmology and neurology sensing of devastating diseases, disrupting the modus operandi of retinal and neuronal imaging without disturbing the modus agendi of the end users.
Research
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Discovery
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Analysis
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Testing
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Project News
5 most important considerations when testing a new drug
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How will nano technology change modern medicine?
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Would you trust a machine to perform procedures?
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“To raise new questions, new possibilities, to regard old problems from a new angle, requires creative imagination and marks real advance in science.”
Meet our Partners
DynAMic comprises a consortium of high interdisciplinarity, covering the fields of optics and photonics (FORTH-IESL), theoretical and experimental physics, mathematics (CNRS), electronics, optronics and mechatronics, engineering and production technology (Rayfos, Imagine Optic), life sciences, biology, biomedicine and medicine (EKUT, FORTH-IMBB) and imaging science and technology (TUM, USTAN). The consortium has unique expertise and interdisciplinarity with proven and demonstrated record of participation and management of European and National research grants. The relevance of the expertise within DynAMic is illustrated by the close collaboration and synergy between the partners.
